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CLCN1

Gene

chloride voltage-gated channel 1

HGNCHGNC:2019EnsemblENSG00000188037NCBI Gene1180
Locus: gene with protein productLocation: 7q34

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCLC1 · ClC-1
View full nomenclature history (5)
Alias symbolsCLC1, ClC-1
Previous nameschloride channel, voltage-sensitive 1, chloride channel 1, skeletal muscle
Alias namesThomsen disease, autosomal dominant

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hyperkalemic periodic paralysis
Genetic Diseases, Inborn
Hypokalemic periodic paralysis, type 1

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CLC chloride channel and transporter family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-02-20.
Open TargetsGene–disease associations from the Open Targets Platform.