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CLPP

Gene

caseinolytic mitochondrial matrix peptidase proteolytic subunit

HGNCHGNC:2084EnsemblENSG00000125656NCBI Gene8192
Locus: gene with protein productLocation: 19p13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

ATP-dependent Clp protease proteolytic subunit, mitochondrialQ16740

Protein · therapeutic target

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (4)
Previous namesClpP (caseinolytic protease, ATP-dependent, proteolytic subunit, E. coli) homolog, ClpP caseinolytic protease, ATP-dependent, proteolytic subunit homolog (E. coli), ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli)
Alias namesATP-dependent protease ClpAP (E. coli), proteolytic subunit, human

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Neoplasms
Parkinson's Disease
Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

AAA ATPases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.