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CLU

Gene

clusterin

HGNCHGNC:2095EnsemblENSG00000120885NCBI Gene1191
Locus: gene with protein productLocation: 8p21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCLI · APOJ · SGP-2 · SP-40 · TRPM-2 · KUB1 · CLU1 · CLU2
View full nomenclature history (13)
Previous symbolsCLI, APOJ
Alias symbolsSGP-2, SP-40, TRPM-2, KUB1, CLU1, CLU2
Previous namesclusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
Alias namescomplement lysis inhibitor, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Alzheimer's Disease
Dementia
late-onset Alzheimers disease
Prostatic Neoplasms
Dengue
Neurodegenerative Diseases
Lewy Body Disease
Refractive Errors

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Complement system regulators and receptorsMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.