CREBBP

Gene

CREB binding lysine acetyltransferase

HGNCHGNC:2348 EnsemblENSG00000005339 NCBI Gene1387

Locus: gene with protein productLocation: 16p13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

CREB-binding proteinQ92793

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRSTS · RTS · CBP · KAT3A

View full nomenclature history (6)

Previous symbolsRSTS

Alias symbolsRTS, CBP, KAT3A

Previous namesCREB binding protein, Rubinstein-Taybi syndrome

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lymphoma, Large B-Cell, Diffuse

Neoplasms

Genetic Diseases, Inborn

Urinary Bladder Neoplasms

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers ZZ-typeLysine acetyltransferasesBromodomain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-05-15.

Open TargetsGene–disease associations from the Open Targets Platform.