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CTNNB1

Gene

catenin beta 1

HGNCHGNC:2514EnsemblENSG00000168036NCBI Gene1499
Locus: gene with protein productLocation: 3p22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Catenin beta-1P35222

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCTNNB · beta-catenin · armadillo
View full nomenclature history (6)
Previous symbolsCTNNB
Alias symbolsbeta-catenin, armadillo
Previous namescatenin (cadherin-associated protein), beta 1 (88kD), catenin (cadherin-associated protein), beta 1, 88kDa, catenin (cadherin-associated protein), beta 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Carcinoma, Hepatocellular
Medulloblastoma
Colorectal Neoplasms
Ovarian Neoplasms
Prostate adenocarcinoma
Listeriosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Armadillo repeat containingBeta cateninsWnt enhanceosome complex

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-04-24.
Open TargetsGene–disease associations from the Open Targets Platform.