CX3CL1

Gene

C-X3-C motif chemokine ligand 1

HGNCHGNC:10647 EnsemblENSG00000006210 NCBI Gene6376

Locus: gene with protein productLocation: 16q21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

FractalkineP78423

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSCYD1 · NTN · C3Xkine · ABCD-3 · CXC3C · CXC3

View full nomenclature history (10)

Previous symbolsSCYD1

Alias symbolsNTN, C3Xkine, ABCD-3, CXC3C, CXC3

Previous namessmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin), chemokine (C-X3-C motif) ligand 1

Alias namesfractalkine, neurotactin

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Arthritis, Rheumatoid

Neoplasms

Carcinoma, Hepatocellular

Lung Diseases, Interstitial

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Chemokine ligands

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.