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CXCL12

Gene

C-X-C motif chemokine ligand 12

HGNCHGNC:10672EnsemblENSG00000107562NCBI Gene6387
Locus: gene with protein productLocation: 10q11.21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Stromal cell-derived factor 1P48061

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSDF1A · SDF1B · SDF1 · SCYB12 · SDF-1a · SDF-1b · PBSF · TLSF-a · TLSF-b · TPAR1
View full nomenclature history (12)
Previous symbolsSDF1A, SDF1B, SDF1
Alias symbolsSCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1
Previous namesstromal cell-derived factor 1, chemokine (C-X-C motif) ligand 12

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Coronary Artery Disease
Myocardial Infarction
Myocardial Ischemia
Angina Pectoris

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Chemokine ligands

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.