CXCR4

Gene

C-X-C motif chemokine receptor 4

HGNCHGNC:2561 EnsemblENSG00000121966 NCBI Gene7852

Locus: gene with protein productLocation: 2q22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

C-X-C chemokine receptor type 4P61073

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asLESTR · NPY3R · HM89 · NPYY3R · D2S201E · fusin · HSY3RR · NPYR · CD184

View full nomenclature history (11)

Alias symbolsLESTR, NPY3R, HM89, NPYY3R, D2S201E, fusin, HSY3RR, NPYR, CD184

Previous nameschemokine (C-X-C motif), receptor 4 (fusin), chemokine (C-X-C motif) receptor 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lymphoma, Non-Hodgkin's

Neoplasms

Lymphoma

Severe congenital neutropenia

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Skin Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesC-X-C motif chemokine receptors

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.