CYP11B2

Gene

cytochrome P450 family 11 subfamily B member 2

HGNCHGNC:2592 EnsemblENSG00000179142 NCBI Gene1585

Locus: gene with protein productLocation: 8q24.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Cytochrome P450 11B2, mitochondrialP19099

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCYP11B · CYP11BL · CPN2 · P-450C18 · P450aldo · ALDOS

View full nomenclature history (9)

Previous symbolsCYP11B

Alias symbolsCYP11BL, CPN2, P-450C18, P450aldo, ALDOS

Previous namescytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2, cytochrome P450, family 11, subfamily B, polypeptide 2

Alias namessteroid 11-beta-monooxygenase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Cushing's Syndrome

Hypertension

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cytochrome P450 family 11

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.