CYP17A1

Gene

cytochrome P450 family 17 subfamily A member 1

HGNCHGNC:2593 EnsemblENSG00000148795 NCBI Gene1586

Locus: gene with protein productLocation: 10q24.32

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Steroid 17-alpha-hydroxylase/17,20 lyaseP05093

Protein · therapeutic target

Clinically validated target · 3 approved medicines against this target

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCYP17 · P450C17 · CPT7 · S17AH

View full nomenclature history (7)

Previous symbolsCYP17

Alias symbolsP450C17, CPT7, S17AH

Previous namescytochrome P450, subfamily XVII (steroid 17-alpha-hydroxylase), adrenal hyperplasia, cytochrome P450, family 17, subfamily A, polypeptide 1

Alias namesSteroid 17-alpha-monooxygenase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency

46,XY disorder of sex development due to isolated 17,20 lyase deficiency

Adrenal Hyperplasia, Congenital

Prostatic Neoplasms

Adrenal gland disorder

17,20-Lyase deficiency, isolated

17-Alpha-hydroxylase/17,20-lyase deficiency, combined complete

17-Alpha-hydroxylase/17,20-lyase deficiency, combined partial

Prostate neoplasm

Cushing's Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cytochrome P450 family 17

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.