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CYP21A2

Gene

cytochrome P450 family 21 subfamily A member 2

HGNCHGNC:2600EnsemblENSG00000231852NCBI Gene1589
Locus: gene with protein productLocation: 6p21.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Steroid 21-hydroxylaseP08686

Protein · therapeutic target

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCYP21 · CYP21B · P450c21B · CPS1 · CAH1 · CA21H
View full nomenclature history (9)
Previous symbolsCYP21, CYP21B
Alias symbolsP450c21B, CPS1, CAH1, CA21H
Previous namescytochrome P450, family 21, subfamily A, polypeptide 2, cytochrome P450, subfamily XXIA (steroid 21-hydroxylase, congenital adrenal hyperplasia), polypeptide 2
Alias namesSteroid 21-monooxygenase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Adrenal Hyperplasia, Congenital
Genetic Diseases, Inborn
Adrenal gland disorder
Hypersensitivity

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cytochrome P450 family 21

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.