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CYP27B1

Gene

cytochrome P450 family 27 subfamily B member 1

HGNCHGNC:2606EnsemblENSG00000111012NCBI Gene1594
Locus: gene with protein productLocation: 12q14.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrialO15528

Protein · therapeutic target

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Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asVDD1 · PDDR · CYP1 · P450c1
View full nomenclature history (10)
Previous symbolsVDD1, PDDR
Alias symbolsCYP1, P450c1
Previous namescytochrome P450, family 27, subfamily B, polypeptide 1, cytochrome P450, subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase), polypeptide 1
Alias namesVDDR I, 1alpha(OH)ase, 25-Hydroxyvitamin D3 1alpha-hydroxylase, Calcidiol 1-monooxygenase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Genetic Diseases, Inborn
Rickets
Arthritis, Rheumatoid
Diabetes Mellitus, Type 1

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cytochrome P450 family 27

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-10.
Open TargetsGene–disease associations from the Open Targets Platform.