CYP8B1

Gene

cytochrome P450 family 8 subfamily B member 1

HGNCHGNC:2653 EnsemblENSG00000180432 NCBI Gene1582

Locus: gene with protein productLocation: 3p22.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylaseQ9UNU6

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCYP12

View full nomenclature history (3)

Alias symbolsCYP12

Previous namescytochrome P450, subfamily VIIIB (sterol 12-alpha-hydroxylase), polypeptide 1, cytochrome P450, family 8, subfamily B, polypeptide 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Liver Diseases

Carcinoma, Hepatocellular

Neoplasms

Progressive familial intrahepatic cholestasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Cytochrome P450 family 8Oxygenases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2026-06-10.

Open TargetsGene–disease associations from the Open Targets Platform.