DDB2

Gene

damage specific DNA binding protein 2

HGNCHGNC:2718 EnsemblENSG00000134574 NCBI Gene1643

Locus: gene with protein productLocation: 11p11.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDDBB · UV-DDB2 · FLJ34321 · XPE

View full nomenclature history (8)

Alias symbolsDDBB, UV-DDB2, FLJ34321, XPE

Previous namesdamage-specific DNA binding protein 2 (48kD)

Alias namesxeroderma pigmentosum group E protein, UV-damaged DNA-binding protein 2, DDB p48 subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Xeroderma Pigmentosum

Prostate carcinoma

Hemangioblastoma

Leukemia, Myeloid, Acute

Cardiomyopathies

Mood Disorders

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

WD repeat domain containingXeroderma pigmentosum complementation groupsNucleotide excision repair

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.