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DDX3X

Gene

DEAD-box helicase 3 X-linked

HGNCHGNC:2745EnsemblENSG00000215301NCBI Gene1654
Locus: gene with protein productLocation: Xp11.4

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asDDX3 · DBX · HLP2 · DDX14 · CAP-Rf
View full nomenclature history (9)
Previous symbolsDDX3
Alias symbolsDBX, HLP2, DDX14, CAP-Rf
Previous namesDEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked, DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
Alias namesHelicase-like protein 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Medulloblastoma
Genetic Diseases, Inborn
Burkitt Lymphoma
Melanoma
Neurodevelopmental Disorders
Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DEAD-box helicases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-04-24.
Open TargetsGene–disease associations from the Open Targets Platform.