DNMT3A

Gene

DNA methyltransferase 3 alpha

HGNCHGNC:2978 EnsemblENSG00000119772 NCBI Gene1788

Locus: gene with protein productLocation: 2p23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

DNA (cytosine-5)-methyltransferase 3AQ9Y6K1

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

View full nomenclature history (1)

Previous namesDNA (cytosine-5-)-methyltransferase 3 alpha

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Myeloid, Acute

Myelodysplastic syndrome

Leukemia, Myeloid

Chronic myelomonocytic leukemia

Neoplasms

Myeloproliferative disorder

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PWWP domain containingMicroRNA protein coding host genes7BS C5-cytosine DNA/RNA methyltransferasesDNA/RNA methyltransferases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.