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DOCK8

Gene

dedicator of cytokinesis 8

HGNCHGNC:19191EnsemblENSG00000107099NCBI Gene81704
Locus: gene with protein productLocation: 9p24.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFLJ00026 · FLJ00152 · ZIR8 · FLJ00346
View full nomenclature history (4)
Alias symbolsFLJ00026, FLJ00152, ZIR8, FLJ00346

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Severe Combined Immunodeficiency
Carcinoma, Squamous Cell
Lymphoma
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Armadillo like helical domain containingDOCK family Rho GEFs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.