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DTL

Gene

denticleless E3 ubiquitin protein ligase adapter

HGNCHGNC:30288EnsemblENSG00000143476NCBI Gene51514
Locus: gene with protein productLocation: 1q32.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRAMP · L2DTL · DCAF2 · CDT2
View full nomenclature history (9)
Alias symbolsRAMP, L2DTL, DCAF2, CDT2
Previous namesdenticleless E3 ubiquitin protein ligase homolog, denticleless homolog (Drosophila), denticleless E3 ubiquitin protein ligase homolog (Drosophila)
Alias namesRA regulated nuclear matrix associated protein, DDB1 and CUL4 associated factor 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Diabetes Mellitus
Diabetes Mellitus, Type 2
Migraine Disorders
Gout
Melanoma
Uterine Cervical Neoplasms
Carcinoma, Hepatocellular

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

WD repeat domain containingDDB1 and CUL4 associated factorsMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-06-27.
Open TargetsGene–disease associations from the Open Targets Platform.