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DUOX2

Gene

dual oxidase 2

HGNCHGNC:13273EnsemblENSG00000140279NCBI Gene50506
Locus: gene with protein productLocation: 15q21.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asP138-TOX · P138(TOX) · THOX2 · LNOX2
View full nomenclature history (10)
Alias symbolsP138-TOX, P138(TOX), THOX2, LNOX2
Alias namesnicotinamide adenine dinucleotide phosphate oxidase, flavoprotein NADPH oxidase, NADPH thyroid oxidase 2, NADH/NADPH thyroid oxidase p138-tox, NADPH oxidase/peroxidase DUOX2, dual oxidase-like domains 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Congenital Hypothyroidism
Genetic Diseases, Inborn
Bilateral striopallidodentate calcinosis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

EF-hand domain containingFlavoproteinsNADH oxidase familyDual oxidase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.