EGR1

Gene

early growth response 1

HGNCHGNC:3238 EnsemblENSG00000120738 NCBI Gene1958

Locus: gene with protein productLocation: 5q31.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Early growth response protein 1P18146

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known as225 · TIS8 · AT225 · G0S30 · NGFI-A · ZIF268 · KROX-24 · ZIF-268

View full nomenclature history (12)

Alias symbols225, TIS8, AT225, G0S30, NGFI-A, ZIF268, KROX-24, ZIF-268

Alias namesnerve growth factor-induced protein A, transcription factor ETR103, zinc finger gene 225, early growth response protein 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases

Atrial Fibrillation

Diabetes Mellitus, Type 2

Carcinoma, Hepatocellular

Carcinoma, Squamous Cell

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers C2H2-type

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-10-04.

Open TargetsGene–disease associations from the Open Targets Platform.