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ELANE

Gene

elastase, neutrophil expressed

HGNCHGNC:3309EnsemblENSG00000197561NCBI Gene1991
Locus: gene with protein productLocation: 19p13.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Neutrophil elastaseP08246

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asELA2 · NE · HNE · HLE · PMN-E
View full nomenclature history (11)
Previous symbolsELA2
Alias symbolsNE, HNE, HLE, PMN-E
Previous nameselastase 2, neutrophil
Alias namesneutrophil elastase, leukocyte elastase, medullasin, PMN Elastase, polymorphonuclear leukocyte elastase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neutropenia
Pulmonary Emphysema
Severe congenital neutropenia

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Granule associated serine proteases of immune defenceComplement system regulators and receptorsElastases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.