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ERCC2

Gene

ERCC excision repair 2, TFIIH core complex helicase subunit

HGNCHGNC:3434EnsemblENSG00000104884NCBI Gene2068
Locus: gene with protein productLocation: 19q13.32

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asXPD · MAG · EM9 · MGC102762 · MGC126218 · MGC126219
View full nomenclature history (11)
Previous symbolsXPD
Alias symbolsMAG, EM9, MGC102762, MGC126218, MGC126219
Previous namesexcision repair cross-complementation group 2, xeroderma pigmentosum complementary group D, excision repair cross-complementing rodent repair deficiency, complementation group 2
Alias namesexcision repair cross-complementing rodent repair deficiency, complementation group 2 protein, TFIIH basal transcription factor complex helicase XPB subunit

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Xeroderma Pigmentosum
Urinary Bladder Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DEAH-box helicasesXeroderma pigmentosum complementation groupsERCC excision repair associatedGeneral transcription factor IIH complex subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.