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ERCC4

Gene

ERCC excision repair 4, endonuclease catalytic subunit

HGNCHGNC:3436EnsemblENSG00000175595NCBI Gene2072
Locus: gene with protein productLocation: 16p13.12

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asXPF · RAD1 · FANCQ
View full nomenclature history (6)
Previous symbolsXPF
Alias symbolsRAD1, FANCQ
Previous namesexcision repair cross-complementing rodent repair deficiency, complementation group 4, excision repair cross-complementation group 4
Alias namesxeroderma pigmentosum, complementation group F

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Xeroderma Pigmentosum
Fanconi Anemia
Cockayne Syndrome
Leukemia, Myeloid, Acute

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

FA complementation groupsXeroderma pigmentosum complementation groupsERCC excision repair associated

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.