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EXO5

Gene

exonuclease 5

HGNCHGNC:26115EnsemblENSG00000164002NCBI Gene64789
Locus: gene with protein productLocation: 1p34.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asC1orf176 · DEM1 · FLJ21144
View full nomenclature history (5)
Previous symbolsC1orf176, DEM1
Alias symbolsFLJ21144
Previous nameschromosome 1 open reading frame 176, defects in morphology 1 homolog (S. cerevisiae)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Non-syndromic male infertility due to sperm motility disorder
Spermatogenic failure
Abortion, Habitual

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Exonucleases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.