EZH2

Gene

enhancer of zeste 2 polycomb repressive complex 2 subunit

HGNCHGNC:3527 EnsemblENSG00000106462 NCBI Gene2146

Locus: gene with protein productLocation: 7q36.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Histone-lysine N-methyltransferase EZH2Q15910

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asEZH1 · ENX-1 · KMT6 · KMT6A

View full nomenclature history (6)

Alias symbolsEZH1, ENX-1, KMT6, KMT6A

Previous namesenhancer of zeste (Drosophila) homolog 2, enhancer of zeste homolog 2 (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Lymphoma, Large B-Cell, Diffuse

Neurodegenerative Diseases

Leukemia, Myeloid, Acute

Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Histone lysine methyltransferasesMyb/SANT domain containingPolycomb repressive complex 2SET domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-11-07.

Open TargetsGene–disease associations from the Open Targets Platform.