FBXW7

Gene

F-box and WD repeat domain containing 7

HGNCHGNC:16712 EnsemblENSG00000109670 NCBI Gene55294

Locus: gene with protein productLocation: 4q31.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asAGO · FLJ11071 · SEL-10 · SEL10 · FBW7 · FBX30 · CDC4 · FBXW6

View full nomenclature history (11)

Alias symbolsAGO, FLJ11071, SEL-10, SEL10, FBW7, FBX30, CDC4, FBXW6

Previous namesF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila), F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase

Alias namesarchipelago homolog (Drosophila)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Colorectal adenocarcinoma

Endometrial Neoplasms

Colonic Neoplasms

Urinary Bladder Neoplasms

Diabetes Mellitus, Type 2

Esophageal Neoplasms

Squamous Cell Carcinoma of Head and Neck

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

WD repeat domain containingF-box and WD repeat domain containingMicroRNA protein coding host genes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.