FGFR2

Gene

fibroblast growth factor receptor 2

HGNCHGNC:3689 EnsemblENSG00000066468 NCBI Gene2263

Locus: gene with protein productLocation: 10q26.13

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Fibroblast growth factor receptor 2P21802

Protein · therapeutic target

Clinically validated target · 11 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKGFR · BEK · CFD1 · JWS · CEK3 · TK14 · TK25 · ECT1 · K-SAM · CD332

View full nomenclature history (16)

Previous symbolsKGFR, BEK, CFD1, JWS

Alias symbolsCEK3, TK14, TK25, ECT1, K-SAM, CD332

Previous namesbacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Jackson-Weiss syndrome

Alias namesCrouzon syndrome, Pfeiffer syndrome

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Crouzon syndrome

Pfeiffer syndrome

Apert syndrome

Beare-Stevenson cutis gyrata syndrome

Jackson-Weiss syndrome

Antley-Bixler syndrome without genital anomalies or disordered steroidogenesis

Neoplasms

Lacrimoauriculodentodigital syndrome

Bent bone dysplasia syndrome 1

LADD syndrome 1

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesI-set domain containingFibroblast growth factor receptor family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.