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FHIT

Gene

fragile histidine triad diadenosine triphosphatase

HGNCHGNC:3701EnsemblENSG00000189283NCBI Gene2272
Locus: gene with protein productLocation: 3p14.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFRA3B · AP3Aase
View full nomenclature history (5)
Alias symbolsFRA3B, AP3Aase
Previous namesfragile histidine triad gene, fragile histidine triad
Alias namesbis(5'-adenosyl)-triphosphatase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Obesity disorder
Major depressive disorder
Diabetes Mellitus
Diabetes Mellitus, Type 2
Schizophrenia
Prostate carcinoma
Carcinoma, Pancreatic Ductal
Exocrine pancreatic carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genesHistidine triad superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.