FLT3

Gene

fms related receptor tyrosine kinase 3

HGNCHGNC:3765 EnsemblENSG00000122025 NCBI Gene2322

Locus: gene with protein productLocation: 13q12.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Receptor-type tyrosine-protein kinase FLT3P36888

Protein · therapeutic target

Clinically validated target · 16 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asSTK1 · FLK2 · CD135

View full nomenclature history (5)

Alias symbolsSTK1, FLK2, CD135

Previous namesfms related tyrosine kinase 3, fms-related tyrosine kinase 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leukemia, Myeloid, Acute

Carcinoma, Hepatocellular

Gastrointestinal Stromal Tumors

Neoplasms

Carcinoma, Renal Cell

Myelofibrosis

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Primary myelofibrosis

Hypothyroidism

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

CD moleculesImmunoglobulin like domain containingCSF1R, KIT, FLT3 receptor tyrosine kinase family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.