Back to discover

FNTA

Gene

farnesyltransferase, CAAX box, subunit alpha

HGNCHGNC:3782EnsemblENSG00000168522NCBI Gene2339
Locus: gene with protein productLocation: 8p11.21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alphaP49354

Protein · therapeutic target

Clinically validated target · 1 approved medicine against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFPTA · PGGT1A · PTAR2
View full nomenclature history (6)
Alias symbolsFPTA, PGGT1A, PTAR2
Previous namesfarnesyltransferase, CAAX box, alpha
Alias namesprotein prenyltransferase alpha subunit repeat containing 2, protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Leukemia, Myeloid, Acute

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Prenyltransferase alpha subunit repeat containingFarnesyltransferase, CAAX box, subunitsProtein geranylgeranyltransferase type I subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2024-03-11.
Open TargetsGene–disease associations from the Open Targets Platform.