FRZB

Gene

frizzled related protein

HGNCHGNC:3959 EnsemblENSG00000162998 NCBI Gene2487

Locus: gene with protein productLocation: 2q32.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asFRZB-1 · FRZB-PEN · FRZB1 · SRFP3 · FRP-3 · SFRP3 · FRE · FRITZ · FZRB · hFIZ

View full nomenclature history (11)

Alias symbolsFRZB-1, FRZB-PEN, FRZB1, SRFP3, FRP-3, SFRP3, FRE, FRITZ, FZRB, hFIZ

Alias namessecreted frizzled-related protein 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Osteoarthritis

Hypertrophic cardiomyopathy 14

Retinitis Pigmentosa

Carcinoma, Hepatocellular

Amyotrophic Lateral Sclerosis

Melanoma

Squamous Cell Carcinoma of Head and Neck

Osteomyelitis

Stomach Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Secreted frizzled-related proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.