FTO

Gene

FTO alpha-ketoglutarate dependent dioxygenase

HGNCHGNC:24678 EnsemblENSG00000140718 NCBI Gene79068

Locus: gene with protein productLocation: 16q12.2

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Alpha-ketoglutarate-dependent dioxygenase FTOQ9C0B1

Protein · therapeutic target

Clinical-stage target · 1 candidate in clinical development

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA1752 · MGC5149 · ALKBH9 · IFEX9

View full nomenclature history (10)

Alias symbolsKIAA1752, MGC5149, ALKBH9, IFEX9

Previous namesFTO, alpha-ketoglutarate dependent dioxygenase, fat mass and obesity associated

Alias namesmRNA N(6)-methyladenine demethylase, alkB homolog 9, alpha-ketoglutarate-dependent dioxygenase, intragenic FTO exon 9 containing transcript

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Obesity disorder

Diabetes Mellitus, Type 2

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Alkylation repair homologs

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2025-12-17.

Open TargetsGene–disease associations from the Open Targets Platform.