FXYD2

Gene

FXYD domain containing ion transport regulator 2

HGNCHGNC:4026 EnsemblENSG00000137731 NCBI Gene486

Locus: gene with protein productLocation: 11q23.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Sodium/potassium-transporting ATPase subunit gammaP54710

Protein · therapeutic target

Clinically validated target · 5 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asATP1G1 · HOMG2 · MGC12372

View full nomenclature history (4)

Previous symbolsATP1G1, HOMG2

Alias symbolsMGC12372

Previous nameshypomagnesemia 2, renal

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Heart Failure

Atrial Fibrillation

Renal hypomagnesemia 2

Autosomal dominant primary hypomagnesemia with hypocalciuria

Diabetes Mellitus, Type 2

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

FXYD domain containing ion transport regulators

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.