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GABBR2

Gene

gamma-aminobutyric acid type B receptor subunit 2

HGNCHGNC:4507EnsemblENSG00000136928NCBI Gene9568
Locus: gene with protein productLocation: 9q22.33

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Gamma-aminobutyric acid type B receptor subunit 2O75899

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGPR51 · HG20 · GABABR2 · GPRC3B
View full nomenclature history (6)
Previous symbolsGPR51
Alias symbolsHG20, GABABR2, GPRC3B
Previous namesG protein-coupled receptor 51, gamma-aminobutyric acid (GABA) B receptor, 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Developmental and epileptic encephalopathy, 59
Neurodevelopmental disorder with poor language and loss of hand skills
atypical Rett syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Gamma-aminobutyric acid type B receptor subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.