GDF15

Gene

growth differentiation factor 15

HGNCHGNC:30142 EnsemblENSG00000130513 NCBI Gene9518

Locus: gene with protein productLocation: 19p13.11

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Growth/differentiation factor 15Q99988

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPLAB · MIC-1 · PDF · MIC1 · NAG-1 · PTGFB

View full nomenclature history (9)

Alias symbolsPLAB, MIC-1, PDF, MIC1, NAG-1, PTGFB

Alias namesprostate differentiation factor, non-steroidal anti-inflammatory drug-activated gene-1, macrophage inhibitory cytokine-1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Hyperemesis Gravidarum

Coffee consumption

Obesity disorder

Obesity due to melanocortin 4 receptor deficiency

Central Nervous System Neoplasms

Neoplasms

Glioblastoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

MicroRNA protein coding host genesTransforming growth factor beta superfamily

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.