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GPN1

Gene

GPN-loop GTPase 1

HGNCHGNC:17030EnsemblENSG00000198522NCBI Gene11321
Locus: gene with protein productLocation: 2p23.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asXAB1 · NTPBP · MBDIN · ATPBD1A · RPAP4
View full nomenclature history (8)
Previous symbolsXAB1
Alias symbolsNTPBP, MBDIN, ATPBD1A, RPAP4
Previous namesXPA binding protein 1, XPA binding protein 1, GTPase
Alias namesRNA polymerase II associated protein 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neurodegenerative Diseases
Non-alcoholic Fatty Liver Disease
Obesity disorder
Diabetes Mellitus, Type 2
Asthma
Prostate carcinoma
MODY
Carcinoma, Hepatocellular
Transient neonatal diabetes mellitus
Neoplasms

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

GPN-loop GTPases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.