GREM1

Gene

gremlin 1, DAN family BMP antagonist

HGNCHGNC:2001 EnsemblENSG00000166923 NCBI Gene26585

Locus: gene with protein productLocation: 15q13.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCKTSF1B1 · CRAC1 · DRM · gremlin · DAND2 · HMPS

View full nomenclature history (12)

Previous symbolsCKTSF1B1, CRAC1

Alias symbolsDRM, gremlin, DAND2, HMPS

Previous namescysteine knot superfamily 1, BMP antagonist 1, gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis), gremlin 1, colorectal adenoma and carcinoma 1

Alias nameshereditary mixed polyposis syndrome, down-regulated in mos-transformed cells

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Colonic Polyps

Colonic Neoplasms

Colon carcinoma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

DAN family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.