GRIA4

Gene

glutamate ionotropic receptor AMPA type subunit 4

HGNCHGNC:4574 EnsemblENSG00000152578 NCBI Gene2893

Locus: gene with protein productLocation: 11q22.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Glutamate receptor 4P48058

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGLUR4 · GluA4 · GLURD · GluR-4 · GluR-D · GLUR4C

View full nomenclature history (8)

Previous symbolsGLUR4

Alias symbolsGluA4, GLURD, GluR-4, GluR-D, GLUR4C

Previous namesglutamate receptor, ionotrophic, AMPA 4

Alias namesGlutamate receptor 4

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Epilepsy

Migraine Disorders

Alcoholism

Lennox-Gastaut syndrome

Epilepsies, Partial

Refractive Errors

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Glutamate ionotropic receptor AMPA type subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.