GUCY1B1

Gene

guanylate cyclase 1 soluble subunit beta 1

HGNCHGNC:4687 EnsemblENSG00000061918 NCBI Gene2983

Locus: gene with protein productLocation: 4q32.1

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Guanylate cyclase soluble subunit beta-1Q02153

Protein · therapeutic target

Clinically validated target · 10 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGUC1B3 · GUCY1B3 · GC-SB3 · GC-S-beta-1

View full nomenclature history (6)

Previous symbolsGUC1B3, GUCY1B3

Alias symbolsGC-SB3, GC-S-beta-1

Previous namesguanylate cyclase 1 soluble subunit beta, guanylate cyclase 1, soluble, beta 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Angina Pectoris

Hypertension

Coronary Artery Disease

Heart Failure

Cardiovascular Diseases

Myocardial Infarction

Pulmonary arterial hypertension

Hypertension, Pulmonary

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Soluble guanylate cyclases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.