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GUCY2D

Gene

guanylate cyclase 2D, retinal

HGNCHGNC:4689EnsemblENSG00000132518NCBI Gene3000
Locus: gene with protein productLocation: 17p13.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asCORD6 · LCA · GUC2D · GUC1A4 · retGC · RETGC-1 · ROS-GC1 · CYGD · LCA1 · ROS-GC
View full nomenclature history (15)
Previous symbolsCORD6, LCA, GUC2D, GUC1A4
Alias symbolsretGC, RETGC-1, ROS-GC1, CYGD, LCA1, ROS-GC
Previous namescone rod dystrophy 6, guanylate cyclase 2D, membrane (retina-specific)
Alias namesrod outer segment membrane guanylate cyclase, retinal guanylate cyclase 1, Leber congenital amaurosis 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Leber Congenital Amaurosis
Cone rod dystrophy
Cone-rod dystrophy
Retinitis Pigmentosa
Genetic Diseases, Inborn

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Transmembrane guanylate cyclases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-06-14.
Open TargetsGene–disease associations from the Open Targets Platform.