HCK

Gene

HCK proto-oncogene, Src family tyrosine kinase

HGNCHGNC:4840 EnsemblENSG00000101336 NCBI Gene3055

Locus: gene with protein productLocation: 20q11.21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Tyrosine-protein kinase HCKP08631

Protein · therapeutic target

Clinically validated target · 2 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asJTK9

View full nomenclature history (2)

Alias symbolsJTK9

Previous nameshemopoietic cell kinase

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

chronic myelogenous leukemia, BCR-ABL1 positive

Precursor Cell Lymphoblastic Leukemia-Lymphoma

Neoplasms

Leishmaniasis, Cutaneous

Breast Neoplasms

Neurodegenerative Diseases

Autoinflammation with pulmonary and cutaneous vasculitis

Hypertension

Essential Hypertension

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

SH2 domain containingSrc family tyrosine kinases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.

Open TargetsGene–disease associations from the Open Targets Platform.