HDAC2

Gene

histone deacetylase 2

HGNCHGNC:4853 EnsemblENSG00000196591 NCBI Gene3066

Locus: gene with protein productLocation: 6q21

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Histone deacetylase 2Q92769

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asRPD3 · YAF1 · KDAC2

View full nomenclature history (3)

Alias symbolsRPD3, YAF1, KDAC2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Neoplasms

Lymphoma, T-Cell, Cutaneous

Multiple Myeloma

Muscular Dystrophy, Duchenne

Neurodegenerative Diseases

Lymphoma, T-Cell

peripheral T-cell lymphoma, not otherwise specified

mature T-cell and NK-cell non-Hodgkin's lymphoma

Breast Neoplasms

Leukemia, Myeloid, Acute

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Histone deacetylases, class IEMSY complexNuRD complex subunitsSIN3 histone deacetylase complex subunitsCoREST complex subunitsMiDAC complex subunitsMIER complex subunitsRERE complex subunits

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.