HDAC6

Gene

histone deacetylase 6

HGNCHGNC:14064 EnsemblENSG00000094631 NCBI Gene10013

Locus: gene with protein productLocation: Xp11.23

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Protein deacetylase HDAC6Q9UBN7

Protein · therapeutic target

Clinically validated target · 8 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asKIAA0901 · JM21 · HD6 · FLJ16239 · PPP1R90 · KDAC6

View full nomenclature history (8)

Alias symbolsKIAA0901, JM21, HD6, FLJ16239, PPP1R90, KDAC6

Alias namesprotein phosphatase 1, regulatory subunit 90, alpha-tubulin deacetylase HDAC6

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

X-linked dominant chondrodysplasia, Chassaing-Lacombe type

Multiple Myeloma

Lymphoma, T-Cell, Cutaneous

Neoplasms

Muscular Dystrophy, Duchenne

Lymphoma, T-Cell

peripheral T-cell lymphoma, not otherwise specified

mature T-cell and NK-cell non-Hodgkin's lymphoma

Breast Neoplasms

Neurodegenerative Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Ring finger proteinsProtein phosphatase 1 regulatory subunitsHistone deacetylases, class IIB

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-09-21.

Open TargetsGene–disease associations from the Open Targets Platform.