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HERC2

Gene

HECT and RLD domain containing E3 ubiquitin protein ligase 2

HGNCHGNC:4868EnsemblENSG00000128731NCBI Gene8924
Locus: gene with protein productLocation: 15q13.1

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asjdf2 · p528 · D15F37S1
View full nomenclature history (4)
Alias symbolsjdf2, p528, D15F37S1
Previous nameshect domain and RLD 2

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Prader-Willi syndrome
Hair color
Neurodevelopmental Disorders
Retinal Diseases

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Zinc fingers ZZ-typeHECT and RLD domain containing E3 ubiquitin protein ligases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.