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HIF1A

Gene

hypoxia inducible factor 1 subunit alpha

HGNCHGNC:4910EnsemblENSG00000100644NCBI Gene3091
Locus: gene with protein productLocation: 14q23.2

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMOP1 · HIF-1alpha · PASD8 · HIF1 · bHLHe78
View full nomenclature history (9)
Alias symbolsMOP1, HIF-1alpha, PASD8, HIF1, bHLHe78
Previous nameshypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Alias namesPAS domain-containing protein 8, Class E basic helix-loop-helix protein 78, Member of PAS protein 1

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Enchondromatosis
Carcinoma, Ductal, Breast
Colorectal adenocarcinoma
Lymphoid neoplasm
Carcinoma of liver and intrahepatic biliary tract

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Basic helix-loop-helix proteinsPAS domain containing

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-03-15.
Open TargetsGene–disease associations from the Open Targets Platform.