HNF1A

Gene

HNF1 homeobox A

HGNCHGNC:11621 EnsemblENSG00000135100 NCBI Gene6927

Locus: gene with protein productLocation: 12q24.31

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

Hepatocyte nuclear factor 1-alphaP20823

Protein · therapeutic target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asMODY3 · TCF1 · HNF1 · LFB1 · HNF1α

View full nomenclature history (6)

Previous symbolsMODY3, TCF1

Alias symbolsHNF1, LFB1, HNF1α

Previous namestranscription factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal factor

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

MODY

Diabetes Mellitus, Type 2

Diabetes Mellitus

Diabetes Mellitus, Type 1

Coronary Artery Disease

Cholelithiasis

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

HNF class homeoboxes

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.

Open TargetsGene–disease associations from the Open Targets Platform.