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HPD

Gene

4-hydroxyphenylpyruvate dioxygenase

HGNCHGNC:5147EnsemblENSG00000158104NCBI Gene3242
Locus: gene with protein productLocation: 12q24.31

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPPD · 4-HPPD · 4HPPD · GLOD3 · HPPD
View full nomenclature history (7)
Previous symbolsPPD
Alias symbols4-HPPD, 4HPPD, GLOD3, HPPD
Previous namesp-hydroxyphenylpyruvate dioxygenase
Alias namesglyoxalase domain containing 3

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Tyrosinemias

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Glyoxalase domain containingOxygenases

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-07-27.
Open TargetsGene–disease associations from the Open Targets Platform.