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HSPA5

Gene

heat shock protein family A (Hsp70) member 5

HGNCHGNC:5238EnsemblENSG00000044574NCBI Gene3309
Locus: gene with protein productLocation: 9q33.3

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asGRP78 · BiP
View full nomenclature history (5)
Previous symbolsGRP78
Alias symbolsBiP
Previous namesheat shock 70kD protein 5 (glucose-regulated protein, 78kD), heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
Alias namesglucose-regulated protein, 78kDa

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Dengue
Neurodegenerative Diseases
Glioblastoma
Neoplasms
Carcinoma, Hepatocellular
Glioma

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

Heat shock 70kDa proteins

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.