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HTR1A

Gene

5-hydroxytryptamine receptor 1A

HGNCHGNC:5286EnsemblENSG00000178394NCBI Gene3350
Locus: gene with protein productLocation: 5q12.3

Encodes

via encodes

The protein product this gene encodes, reached through the canonical GENE→PROTEIN (encodes) relation. Its biology, drugs, indications, trials and therapeutic evidence live on the protein's own page.

5-hydroxytryptamine receptor 1AP08908

Protein · therapeutic target

Clinically validated target · 17 approved medicines against this target

Explore protein biology & therapeutics

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asADRB2RL1 · ADRBRL1 · 5-HT1A
View full nomenclature history (5)
Previous symbolsADRB2RL1, ADRBRL1
Alias symbols5-HT1A
Previous names5-hydroxytryptamine (serotonin) receptor 1A, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Major depressive disorder
Schizophrenia
Bipolar Disorder
Anxiety Disorders
Autistic Disorder
Psychotic disorder
bipolar I disorder
Depressive Disorder
Tourette's Syndrome

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

5-hydroxytryptamine receptors, G protein-coupled

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.