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HTRA1

Gene

HtrA serine peptidase 1

HGNCHGNC:9476EnsemblENSG00000166033NCBI Gene5654
Locus: gene with protein productLocation: 10q26.13

Also known as

Symbols and names change; identity (the HGNC ID) does not. Previous and alternative forms are kept distinct.

Also known asPRSS11 · HtrA · IGFBP5-protease · ARMD7
View full nomenclature history (5)
Previous symbolsPRSS11
Alias symbolsHtrA, IGFBP5-protease, ARMD7
Previous namesprotease, serine, 11 (IGF binding)

Associated diseases

via associated_with

Diseases linked to this gene through the canonical GENE→DISEASE (associated_with) relation, drawn from Open Targets' top-ranked associations by overall score — not the full association set. Disease-level detail lives on each disease's own page.

Macular Degeneration
Wet macular degeneration
Coronary Artery Disease

Drawn from Open Targets’ top 10 associations by overall score for this gene — the subset resolved to a canonical disease. Lower-ranked associations, and diseases not yet canonicalised, are not shown.

Gene family

HGNC gene-group membership.

PDZ domain containingHtrA serine protease family

Provenance

HGNCCanonical human gene identity from HGNC (release 2026-07-07), updated 2023-01-20.
Open TargetsGene–disease associations from the Open Targets Platform.